Fifteen speakers representing MGH and institutions from ’round the to the max will convene to stake knowledge forth on causes and treatments for Degos disease. Degos disease is a systemic upset that causes small and medium arteries to become blocked so that blood can not easily make off through the body. During the first stage of the disease, characteristic skin lesions appear on the body that can last someone is concerned weeks to years. The second stage is characterized by lesions in the brain and small intestine, which can lead to potentially biography-impending complications. The exact agency of Degos disease remains humble.

Sandra Clancy, family guide in the Coordinated Attend to Clinic at MGHfC, had a young son breathe one’s last of Degos disease in 2004. “After being diagnosed when he was five years old, my son was acknowledged an innovative therapy that unfortunately did not work in his case,” says Clancy, who helped organize the event. “Hopefully, in this symposium setting, ideas and experiences can be exchanged that will help other Degos ailment patients in the future.”

“Once you’ve seen the unique rash of Degos malady, you in no way ignore it,” says John Whelan, MD, a pediatric rheumatologist for the MGHfC. “We have the benefit with this symposium of bringing together a large group of patients who can improve us make up for all the textbooks that provide no pictures and so thimbleful information involving this potentially fatal condition.”

Following the afternoon symposium, participants will be joined by rheumatologists from approximately the world for a writing-room group on Degos and related diseases at the American College of Rheumatology’s annual meeting at the Boston Council Center.

Massachusetts General Sanatorium, established in 1811, is the starting and largest teaching hospital of Harvard Medical School. The MGH conducts the largest polyclinic-based research program in the Unanimous States, with an annual research budget of nearly $500 million and worst probing centers in AIDS, cardiovascular research, cancer, computational and integrative biology, cutaneous biology, android genetics, medical imaging, neurodegenerative disorders, regenerative medicine, transplantation biology and photomedicine. MGH and Brigham and Women’s Asylum are founding members of Partners HealthCare HealthCare Routine, a Boston-based integrated salubrity sorrow delivery system.

http://www.massgeneral.org

The statistics from the four states-Delaware, Hawaii, New York, and Rhode Atoll-may not reflect national trends. But an additional haunt conducted by CDC utilizing data from the Resident Health Interview Study indicated that across all age groups the percentage of adults who, on average, make public sleeping six hours or less has increased from 1985 to 2006.

Nationwide, an estimated 50 to 70 million people suffer from chronic sleep waste and drop disorders. Catch loss is associated with health problems, including obesity, depression, and certain endanger behaviors, including cigarette smoking, medical man inertness, and heavy drinking.

“It’s important to better conscious of how slumber impacts people’s overall healthfulness and the dearth to take steps to improve the sufficiency of their sleep,” said Lela R. McKnight-Eily, Ph.D., the study’s lead originator and a behavioral scientist in CDC’s Disagreement of Adult and Community Health. “There are very few studies to assess and address repose insufficiencies; therefore, more needs to done to better allow the problem and to develop effective sleep interventions.”

The weigh, “Perceived Insufficient Recline or Sleep–Four States, 2006,” analyzed statistics from CDC’s Behavioral Risk Factor Reconnaissance System (BRFSS) survey. Among the four states, the percentage of adults who reported not getting enough rest or sleep every hour in the past 30 days ranged from 14 percent in Delaware to 8 percent in Hawaii.

People disturbed about habitual repose detriment should consult a physician someone is concerned an assessment and possible treatment, such as behavioral or medical interventions, McKnight-Eily said. They can also examine setting a regular drop schedule and avoiding caffeine or other stimulants before bed, she said.

Variation towards insufficient support and catch forty winks may be due to occupational or lifestyle factors. The causes of log a few zees Z’s loss could include energetic schedules or shift have a job; irregular sleep schedules; or lifestyle factors such as acute family demands, unpunctual-unceasingly television watching and Internet use, or the service of caffeine and alcohol, according to a 2006 Institute of Medicament reveal. The Jingoistic Sleep Origination reports that most adults extremity 7-9 hours of sleep each night to feel fully rested while school children grey 5-12 years require 9-11 hours, and adolescents aged 11-17 years instruct 8.5-9.5 hours each gloom.

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The examine also develop that the frequency of too little snooze decreased with age. An estimated 13.3 percent of adults venerable 18-34 reported insufficient excess or have a zizz diurnal in the past month compared to only 7.3 percent of adults ages 55 and older. While some studies have found doze disturbance more governing among older adults, results from this study are consistent with other research that supports the opinion that older adults (who are more likely to be retired) make fewer complaints with regard to impaired sleep and adapt their comprehension of what encompasses adequate sleep.

In summation, the study showed that only one out of three (29.6 percent) adults said they did get ample rest or sleep every day in the past month.

The MMWR report said the definitions of “enough” (sufficient) doze and “rest,” and responses to the survey question were prejudiced and were not measured or equated to reports of hours of log a few zees Z’s per night. The report said the analysis cannot be compared directly with studies measuring hours of sleep. The inspection question also did not define or discern between “rest” and “sleep.”

The office comes nothing but before National Sleep Awareness Week®, an annual contest held in conjunction with Daylight Qualifying Time. For more poop on Citizen Sleep Awareness Week®, held March 3-9, want fall upon http://www.sleepfoundation.org.

Fitted more information on CDC’s Sleep and Catch Disorders Program, like visit http://www.cdc.gov/sleep.

Centers for Disease Control and Prevention’s

This year’s donations will be given to:

Horizons for the treatment of Homeless Children (HHC), the concert-master in Massachusetts and the nation in providing care for young children whose lives have been shattered by homelessness. The mission of HHC is to improve the lives of unhoused knights of the road children and their families. HHC provides homeless children in Massachusetts with the nurturing, stimulation, and opportunities in return early lesson and play that all children need to learn and lengthen in healthy ways. To repair the lives of the children it serves over the desire term, it connects their parents with the tools they basic to complete collective and commercial self-sufficiency. HHC provides management in advocating for exiled children and their families through leveraging and sharing its expertise with others and advocating with policy makers and the public.
Womanshelter/Compañeras was founded by three women activists all named Jane in 1980 as a grassroots collective. What began as a hotline and counseling program soon added a classified shelter and support and advocacy services. Today, the program holds fast to its founding principles and has evolved into a paramount provider of intervention and prevention services in western Massachusetts, having provided shelter to more than 2,000 women and children and assisting 30,000 others through community-based support programs.
The Greater Brockton Salutary Families program is a home visiting program designed to be supportive of unknown families by building upon individual strengths to increase positive family dynamics. The program is voluntary, free, and confidential to all first time parents who meet the eligibility requirements. The program’s pursuit is to improve the fitness and well-being of individuals, families, and communities. To accomplish this, the codification promotes reassuring decision-making skills, provides counter-agent health and group services, and encourages supportive community institutions, which optimize beneficent quiescent.

ACNM offers special thanks to ACNM members, GlaxoSmithKline Consumer Healthcare, and Conceivex, Inc. for their generous donations.

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The ACNM Blankets for Babies national public service campaign seeks to greet local area newborns with a warm, new blanket in the host city of their Annual Meeting & Exhibit each year. ACNM launched the Blankets for Babies campaign in April 2000.

http://www.midwife.org

Unlike duct stick or glue, the renewed material is crafted from millions of wee, hard, plastic fibers that create grip; a bare square two centimeters on a side can support 400 grams (close to a pound). While ribbon sticks when it presses onto a surface, the new adhesive sticks as it slides on a surface and releases as it lifts — this is the trick behind a gecko’s rapid vertical escapes.

The uncharted investigation appeared online in the Tabloid of the Royal Society Interface.

There are other plastic adhesives inspired by gecko feet and they adhere much be fond of conventional fillet. In contrast, the fashionable adhesive brushes along a appear to develop adhesion. While pattern for hanging posters, the property is even more weighty for any application that requires movement, such as climbing.

“The gecko has a altogether with it hierarchical structure of compliant toes, microfibers, nanofibers and nanoattachment plates that allows the foot to attach and unchain with very inconsiderable effort,” said co-writer and Berkeley professor Ron Fearing, “The gecko makes it look simple, but the crude needs to handle the directions it is poignant its toes–correct position equates to little essay,” he said.

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The new temporal is also novel in that it gets stronger with interest. In experiments, it tightened its hold as it was rubbed recurrently against a looking-glass plate. The extra strength is caused by the fibers bending over to make more get in touch with, but once released, the fibers returned to their original improve. The research team is exploring ways to permanently bend the fibers so that the grip strength is its strongest from the inception, no massaging required.

According to Fearing, the new material is the in the beginning to mimic the genre of the gecko’s characteristic “non-sticky by default” feet. The Berkeley researchers, all engineers, have worked closely with biologists Robert Full, also at Berkeley, and Kellar Autumn of Lewis and Clark College in Portland, Ore., to uncover the style basic properties behind that unique foot, the shrouded to momentous mobility on unqualified surfaces.

Fearing and his colleagues are instances partly of an NSF-supported Nanoscale Interdisciplinary Inquiry Team (NIRT) that was specifically tasked in 2003 with developing biologically-inspired synthetic gecko adhesives.

“The results of this project are an powerful illustration of how teaming engineers with biologists results in a preferably handle on of the role of ‘engineering’ in nature,” says Lynn Preston, the NSF officer who supported these NIRT researchers, and numerous other teams of engineers and biologists, through her leadership of NSF’s Engineering Investigating Centers program. “This is a inimitable eg of how to turn that understanding into products that are as sophisticated as those developed by ‘Mother Nature’.”

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Article adapted by Medical Info Today from original press hand out.
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Click here to outlook images.

Click here for additional details about the examine.

Click here to over a video showing the video directed testing in the laboratory.

Source: Josh Chamot

Popular Science Foundation

The multi-centre whirl require study the effectiveness of surgery versus ‘anti-hormone medications as treatment of early breast cancer in women over 75.

Alongside this trial, researchers from the Breast Pioneer at NUH and the University of Nottingham will study the biological features of bust cancer, the long-rates b standing outcome and impact on worth of enthusiasm for different treatment options including surgery and drug therapies.

The Nottingham performance is being led by Mr KL Cheung, Clinical Associate Professor/Consultant Bosom Surgeon and Clinical Lead for breast cancer services at NUH, and Professors Ian Ellis and Davina Porock from the University of Nottingham.

“NUH is well placed to take an active post in this nation-wide look at,” explained KL Cheung, “because we have a artistic deal of experience in developing services specifically aimed at women during the course of 70. When the Nottingham Breast Unit was established some three decades ago, we recognised the need to develop services targeted specifically at women in this age group and we consequently set up a clinic specifically for this team of patients led by consultants and expert nurses. This service has recently developed into a combined surgical and oncology help with support from Dr DAL Morgan, Doctor Clinical Oncologist.”

“This entire programme and the multi-centre study commitment help us gain a greater understanding of the development of breast cancer in older women and the effectiveness of the various treatments available. We will then be able to improve treatment and services for the the better of women with mamma cancer.”

Nottingham University Hospitals NHS Empower was named one of the crest five teaching Trusts in the UK in the 2007 ‘Good Hospital Guide’ by condition information master Dr Foster. The guide says that quantity the key factors of this ascendancy were potent partnership working and high-pitched quality information. The exactly guide can be read here.

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NUH is one of the largest Trusts in the UK, with an annual budget of more than £630 million. It was formed on 1 April 2006, when two crest-rated trusts – Queen’s Medical Pivot and Nottingham City Hospital – merged in quiet to develop a organize of high-quality, sustainable unfaltering services across the two campuses. As a major teaching Corporation, NUH enjoys completion links with the city’s universities and attracts and develops the highest calibre of staff. It continues to be the hospital of choice proper for patients, spur on investment and be left at the forefront of research. It has a particular of the busiest difficulty departments in the UK and has over 1,650 medical centre beds across both campuses.

NUH

While it is known that college students are more likely to engage in hazardous drinking behaviour than young adults not attending college, little research outside of North America has been conducted on the issue.

The study by researchers from the University of Newcastle in Australia examined hazardous drinking among undergraduate students attending the University of Otago and found that binge drinking, as well as related health, social and legal problems – is pervasive.

Dr. Kypros Kypri, senior research fellow at Newcastle University says previous studies in New Zealand, conducted at single universities, suggested a high prevalence of binge drinking and alcohol-related harm and they wanted to ensure that this wasn’t a local phenomenon.

Dr. Jennie Connor, public health physician and senior lecturer in epidemiology at the University of Otago says the study shows that the “extreme” drinking patterns of university students are very widespread in New Zealand.

Dr. Connor says the feature of New Zealand university students which may differ from other countries is the low proportion of abstainers from alcohol, which suggests being a non-drinker may make a student a relative ‘outsider,’ whereas in colleges with higher proportions of non-drinkers there may be more options for a peer group that doesn’t drink much.”

For the study the researchers compiled web-survey responses from 2,548 undergraduates (1,542 females, 1,006 males) enrolled at five of New Zealand’s eight universities – the students were asked to provide information on drinking patterns and alcohol-related problems during the preceding four weeks, and also complete “drinking diaries” for the preceding seven days.

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Dr. Kypri says more than 80% of both men and women reported drinking alcohol in the seven days preceding the survey and 37% reported binge drinking in the seven days preceding the survey.

There was also a high prevalence of alcohol-related problems – 33% of students experienced blackouts in the preceding four weeks.

The risk factors for binge drinking included being younger, starting to drink earlier, being a binge drinker in high school, and living with other students and Dr. Connor says the majority of New Zealand university students, women as well as men, are drinking in a hazardous or harmful way, and this is common.

The drinking was associated with frequent adverse events, including one in 10 students being exposed to a drunk-driving trip during the preceding four weeks and Dr. Kypri says this prevalence of drinking is higher than reported in the USA and Canada.

The researchers recommend that priority status be given to the reduction of binge drinking in high school, given its strong association with later binge drinking and say their finding underlines the need for strategies to prevent and ameliorate drinking problems before young people arrive at university.

In New Zealand the minimum purchase age for alcohol was lowered from 20 to 18 years and has probably made drinking among 15 -17 year-olds worse and therefore the job of universities all the more difficult.”

Dr. Kypri has called for a coordination of effort – by central government, local government, police, health authorities and universities – to reduce the availability and promotion of alcohol on and around campuses.

He also recommends that universities implement early identification systems to address drinking problems among students as early as possible in their university careers and says measures are needed to restrict availability of alcohol to young people through regulation of supply, increasing price, and reducing high levels of alcohol promotion around campuses.

Dr. Connor says the study provides evidence to support giving advice to families about the value of delaying initiation of drinking, becoming aware of the level of exposure young people have to a heavy-drinking peer culture, and how frequent adverse events are.

Dr. Jennie Connor, lecturer in epidemiology at Otago University and research associate with the Injury Prevention Research Unit, says international evidence shows that increasing taxes and raising the purchase age reduces the level of alcohol-related harm.

The research will be published in the February 2009 issue of Alcoholism: Clinical & Experimental Research and are currently available at Early View.

“Reprinted with permission from http://www.kaisernetwork.org. You can aim the undamaged Kaiser Everyday Health Policy Publicize, search the archives, or spur up exchange for email delivery at http://www.kaisernetwork.org/dailyreports/healthpolicy. The Kaiser Daily Robustness Procedure Report is published for kaisernetwork.org, a free service of The Henry J. Kaiser Derivation Foundation . © 2005 Advisory Board Company and Kaiser Household Foundation. All rights unemotional.

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These data from the ECOG E4A03 and SWOG 0232 studies, which were recently presented at the American Society of Clinical Oncology (ASCO) Annual Joining. More specifically, updated results from these two in a body cooperative group trials of REVLIMID in combination with dexamethasone in newly diagnosed patients reported a survival advantage and improved consummate comeback rates for REVLIMID when combined with dexamethasone.

In a four-month landmark analysis of ECOG Remove III study E4A03, patients who continued on treatment of REVLIMID plus sad-measure dexamethasone (Rd) achieved a two-year whole survival rate of 93 percent. In the same milestone analysis, patients who went on to autologous stem room transplant achieved the having said that two-year survival rate of 93 percent.

Patients in the guidepost analysis who received Rd achieved an overall response rate of 89 percent and CR + VGPR of 56 percent. Patients in the SWOG 0232 Condition III study receiving REVLIMID gain dexamethasone (RD) achieved a progression-cost-free survival rate of 77 percent at one year and CR + VGPR of 62 percent.

Results from these studies show that REVLIMID in combination with dexamethasone is immensely active in newly diagnosed multiple myeloma regardless of age or displace eligibility. In addition, results from the trials get ready for the reasoning allowing for regarding conducting tomorrow prospective trials comparing tale agents to develop chamber move.

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“REVLIMID is turning multiple myeloma into a chronic disease through dependable infection control, manageable side effects, and the freedom of pronounced dosing” commented Dr Brian Durie, Chairman of the Board and Co-Founder, Foreign Myeloma Foundation (IMF).

Additional Data Support REVLIMID’s Efficacy in Newly Diagnosed Patients

In a study conducted by the Eastern Cooperative Oncology Bring (E4A03) of REVLIMID plus low-dose dexamethasone (Rd) versus REVLIMID advantage a pillar dose of dexamethasone (RD) in newly diagnosed multiple myeloma patients, clinicians reported unmixed response rates that had not been tabulated at previous presentations. Patients in the Rd arm of the workroom demonstrated a combined imminent complete response/very secure partial response (nCR/VGPR) standing of 52 percent in the Rd arm compared to 42 percent in the RD arm (P=0.06). Also reported was a two-year overall survival of 88 percent fitting for the Rd arm compared to 78 percent in the RD arm (p=0.007).

Grade 3 or higher non-hematologic toxicities in the RD vs. Rd arms of the reflect on included the waves style thrombosis (DVT)/pulmonary embolism (PE) (25% vs. 11%) infection/pneumonia (16% vs. 8%) cardiac ischemia (3% vs. 0.5%) and neuropathy (2% in both arms).

The Southwest Oncology Group also presented at ASCO updated results of a retreat (SWOG 0232) evaluating REVLIMID plus dexamethasone (RD) versus dexamethasone (D) alone in newly diagnosed multiple myeloma patients. Highlighted in the visuals was a combined complete response rate (CR) plus darned extensive fond of answer speed (VGPR) of 62 percent fit RD compared to 19 percent in the course of dexamethasone (p

This research appears as the “Paper of the Week” in the April issue of the Memoir of Biological Chemistry, an American Sodality for Biochemistry and Molecular Biology journal.

Kaposi sarcoma is the most frequent tumor in AIDS patients and is caused by infection of the patients with the Kaposi sarcoma-associated herpes virus. The Kaposi sarcoma virus genome contains sequence that encodes for a protein called viral G protein-coupled receptor (vGPCR) that plays a essential job in the development of tumoral lesions.

Interestingly, a study done in inappropriate 2004 showed that the cellular television of a protein called heme oxygenase-1 could be turned on by the Kaposi’s sarcoma-associated herpesvirus. Heme oxygenase-1 is an enzyme that is expressed in spleen and liver and is liable for breaking down heme, a molecule that consists of an iron atom surrounded by a large ring of other atoms. Further denote of the connection between heme oxygenase-1 and the Kaposi’s sarcoma virus came when distinguished levels of the protein were detected in biopsy tissue from oral AIDS-Kaposi’s sarcoma lesions.

“Taking into account the predominant purpose of vGPCR in Kaposi’s sarcoma and the prominent enunciation of heme oxygenase-1 observed in Kaposi’s sarcoma lesions, we sure to study whether vGPCR could enlargement heme oxygenase-1 expression and if so, to explore the putative role of the enzyme in vGPCR-dependent transformation,” explains learning father Maria Julia Marinissen of the Universidad Autonoma de Madrid.

Marinissen and her colleagues found that vGPCR does certainly increase production of the heme oxygenase-1 protein and the RNA that codes for it. They also discovered that mice with tumors that were delineated specific pharmacological inhibitors that blocked heme oxygenase-1 liveliness showed a significant reduction in tumor growth without apparent side effects.

“Considering that heme oxygenase-1 is overexpressed in vulnerable Kaposi’s sarcoma lesions, the defence of intratumoral heme oxygenase-1 liveliness by currently available drugs can represent a new anticancer orchestration in the treatment of Kaposi’s sarcoma and may be of implicit clinical interest after more comprehensive study,” says Marinissen. “The inhibitor that we used in this ruminate on is a tin-protoporphyrin. A modern clinical trial showed that the inhibitor can be administered to newborns at any time point in the progression of postnatal hyperbilirubinemia to in two shakes of a lamb’s tail and predictably block heme degradation and prevent exigent jaundice without expressive short- or protracted-appellation side effects. This is very important because it shows that the inhibitor has been successfully used in lenient clinical trials to treat diseases in which heme oxygenase-1 is involved.”

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Article adapted by Medical News Today from original press publicity release.

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The Daily of Biological Chemistry’s Papers of the Week is an online feature that highlights the top one percent of papers received by the journal. Brief summaries of the papers and explanations of why they were selected through despite this honor can be accessed directly from the national page of the Journal of Biological Chemistry online at http://www.jbc.org/.

The American Society for Biochemistry and Molecular Biology (ASBMB) is a nonprofit scientific and educational make-up with down 11,000 members in the United States and internationally. Most members teach and conduct research at colleges and universities. Others conduct research in various government laboratories, nonprofit research institutions, and industry.

Founded in 1906, the Society is based in Bethesda, Maryland, on the campus of the Union of American Societies for Experiential Biology. The Society’s primary goal is to improve the sciences of biochemistry and molecular biology through its publications, the Journal of Biological Chemistry, the Journal of Lipid Delve into, Molecular and Cellular Proteomics, and Biochemistry and Molecular Biology Education, and the holding of well-organized meetings.

For more information about ASBMB, look at the Society’s website at http://www.asbmb.org/.

Connection: Nicole Kresge
American Society in the interest Biochemistry and Molecular Biology

Fetal programming and childhood factors have been associated with serious adult health risks, such as obesity, heart disease, and cancer.

The researchers monitored the health of 171 men and 218 women, all of whom were part of the Newcastle Thousand Families Birth Cohort Study.

This study collected comprehensive information on birth and childhood factors, and has regularly tracked the health of 1000 babies born in May and June 1947 in Newcastle upon Tyne, north eastern England.

Of the original cohort, 832 adults were traced at the ages of 49 to 51. Of these, 389 (171 men and 218 women) completed a detailed health and lifestyle questionnaire and underwent tests to gauge bone mineral density (BMD) of the hip, spine, and top of the thigh bone (femur).

For men, birthweight was a significant factor for bone size, while birthweight was a significant factor for BMD. For women, the size of the head of the thigh bone was associated with increasing socioeconomic advantage at birth.

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But all in all, these factors accounted for less than 7% of the variation in BMD in men and for less than 1% in women.

For both sexes, almost half of the variation in BMD explained by early childhood factors was mediated through weight in adulthood

Increasing numbers of pregnancies lowered hip BMD in women. Vitamin C intake also seemed to be important for men.

And, overall, adult lifestyle and body size accounted for most of all the variation in the indicators of bone health at age 49-51 in both sexes. Adult weight was a particularly important factor for women, and accounted for 25% of the variation in BMD.

The authors conclude that while “birthweight does seem to influence skeletal growth, adult lifestyle and body size seem to be the most important determinants of bone health in middle age in this cohort.” Cutting the risk of poor bone health in middle age means adopting a healthy lifestyle, they add.

Contacts:

Dr Mark Pearce, Sir James Spence Institute of Child Health, Royal Victoria Infirmary, Newcastle upon Tyne, UK Tel: +44 (0)191 202 3082 (not available until after May 24) Email: m.s.pearce@ncl.ac.uk

or

Dr Roger Francis, Musculoskeletal Unit, Freeman Hospital, Newcastle upon Tyne, UK Tel: +44 (0)191 223 1160 Email: roger.francis@tfh.nuth.northy.nhs.uk

or

Professor Louise Parker, Sir James Spence Institute of Child Health, Royal Victoria Infirmary, Newcastle upon Tyne, UK Tel: +44 (0) 7768 418 327 Email: louise.parker@ncl.ac.uk

Click here to view the paper in full

http://adc.bmjjournals.com/